Research Interests
Enzymes are dynamical systems that perform homeostatic abilities, in precise control of their local environment through inter-conversions of chemical and mechanical energy and self-regulating feedback connections organized hierarchically across many scales of states. However, little is currently known about the fundamental molecular mechanisms by which enzymes sense mechanical force or deformation, and transducer the mechanical signal into a chemical/biological response. Dr. Yang’s research is directed primarily toward developing and applying modern computational, theoretical capabilities and designed experiments for the understanding and prediction of chemical and physical processes ranging from the molecular to the nanoscale to comprehensive applications, elucidating the mechanistic and stereochemical course of electrocyclic organic reactions, characterizing processes and the nature of inter- and intramolecular interactions governing complex structure, molecular recognition, etc. by which are degraded in physical chemistry and biophysics. The inspiration that X-rays could reveal the crystallographic structures inevitably gave way to the perspiration required to solve more and more complicated biological macromolecules in solutions. X-ray/Neutron scattering has been applied more recently to the study of biomolecules, starting from the late 1980s, but the method, particularly in difficulty of data analysis, is now established as an indispensable tool for their application of structures can be mapped. Dr. Yang has focuses on the SAXS data analysis by incorporating innovated methodologies of computational chemical dynamics that allow one to meaningfully interpret the scattering data from monodisperse systems, from transient complexes as well as flexible and heterogeneous systems in terms of structural models. Yang’s group current interest has focused on the hybrid approaches utilizing SAXS with high-resolution molecular dynamics simulation techniques, but also with biochemical, biophysical, and numerical programming methods by a series of breakthrough experiments with the synchrotron/neutron beamline (TLS 23A at NSRRC/ QUOKKA at ANSTO) and developed computational techniques for solving the inverse mapping problems of X-ray/neutron scattering. Dr. Hsiao-Ching Yang’s research makes efforts to open the field to a new avenue with explosive positive development of value for pure science and practical applications.

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Education & Academic Qualifications

2004	Ph.D., National Sun Yat-Sen University
1999	B.S., National Sun Yat-Sen University

Experiences

• 2019/02~ Professor, Department of Chemistry, Fu-Jen Catholic University
• 2012/02~2019/01 Associate Professor, Department of Chemistry, Fu-Jen Catholic University
• 2006/08~2012/01 Assistant Professor, Department of Chemistry, Fu-Jen Catholic University
• 2006 Postdoctoral Research Associate, The Ohio State University
• 2004-2005 Postdoctoral Research Associate, National Taiwan University

Honors and Awards

• 2016 Ministry of Science and Technology, Ta-You Wu Memorial Award, Taiwan
• 2015 Fu Jen Catholic University, Outstanding Research Award, Taiwan
• 2013 the 62nd SPSJ “Asia Excellence Award”, Japan
• 2012 NSC Research Award, Taiwan
• 2011 Science Editors Choice, 2011, 333, 500. C&EN Concentrates, 2011, 89 (30).
• 2011 Fu Jen Catholic University Outstanding Research Award, Taiwan
• 2011 Chinese Chemical Society Honorable Mention Poster Award, Taiwan
• 2011 Polymer Society Annual Meeting Best Poster Award, Taiwan
• 2011 Polymer Society Annual Meeting Honorable Mention Poster Paper Award, Taiwan
• 2010 Polymer Society Annual Meeting Best Poster Award, Taiwan
• 2008 the 42nd World Polymer Congress (Macro 2008) International Young Polymer
• Scientist Invited Speaker, Taipei

Field

• Main field:PHYSICAL CHEMISTRYS, Computational Chemical Dynamics of Complexed Systems
• Other fields:Mapping of enzymatic process and kinetics by fluorescence lifetime methods and X-ray/neutron scattering imaging.
• Current research interests:Development and application of advanced computational chemical dynamics methods for X-ray/neutron scattering data analysis of biomolecules in solution.

Recent Publications

Google Scholar Link

1.       “Substrate Channeling of Prostaglandin H2 on the Stereochemical Control of a Cascade Cyclization Route” Hsiao-Ching Yang*, Yung-Chi Ge, Cheng-Han Yang , and Wei-Chih Chao, ACS catalysis 2018, 8, 2534-2545.

2.        “Homology Modeling and Molecular Dynamics Simulation Combined with X-ray Solution Scattering Defining Protein Structures of Thromboxane and Prostacyclin Synthases”  Hsiao-Ching Yang*, Cheng-Han Yang, Ming Yi Huang, Jyh-Feng Lu, Jinn-Shyan Wang, Yi-Qi Yeh, U-Ser Jeng, J. Phys. Chem. B 2017, 121, 11229-11240.

3.       “The In Situ Tryptophan Analogue Probes the Conformational Dynamics in Asparaginase Isozymes” Wei-Chih Chao, Jiun-Yi Shen, Cheng-Han Yang, Yi-Kang Lan, Jui-Hung Yuan, Li-Ju Lin, Hsiao-Ching Yang*, Jyh-Feng Lu, Jinn-Shyan Wang, Kevin Wee, You-Hua Chen, Pi-Tai*, Biophysical Journal 2016, 10, 1732–1743.

4.        “Probing Water Environment of Trp59 in Ribonuclease T1: Insight of the Structure−Water Network Relationship” Wei-Chih Chao, Jiun-Yi Shen, Jyh-Feng Lu,*,Jinn-Shyan Wang,*, Hsiao-Ching Yang,*, Kevin Wee, Li-Ju Lin, Yi-Ching Kuo, Cheng-Han Yang, Shih-Hui Weng, Huai-Ching Huang, You-Hua Chen, and Pi-Tai Chou*,  J. Phys. Chem. B ,2015, 119, 2157.

5.       “Probing Micro-solvation in Proteins by Water Catalyzed Proton Transfer Tautomerism” Jiun-Yi Shen, Wei-Chih Chao, Chun Liu, Hsiao-An Pan, Hsiao-Ching Yang*, Chi-Lin Chen, Yi-Kang Lan, Li-Ju Lin, Jinn-Shyan Wang, Jyh-Feng Lu, Steven Chun-Wei Chou, Kuo-Chun Tang and Pi-Tai Chou* Nature Communication 2013, 4, 2611.

6.       “On the Stereoselectivity of Ring Opening Metathesis Polymerization (ROMP) of N-Arylpyrrolidine-Fused Cyclobutenes with Molybdenum- and Ruthenium-Alkylidene Catalysts” Nai-Ti Lin; Satyanarayana, K.; Yi-Kang Lan, Hsiao-Ching Yang, and Tien-Yau Luh*, Macromolecules, 2013, 46 (18), 7173.

7.         “Ambipolar carrier transport properties in a built-indonor–acceptor discogen” Li-Yin Chen, Fei-Hsiung Chien*, Yen-Wei Liu, Wenjun Zheng, Cheng-Yan Chiang, Chia-Yi Hwang, Chi-Wi Ong, Yi-Kang Lan, Hsiao Ching Yang, Organic Electronics 2013, 14 (8), 2065-2070.

8.         “Vitamin E Facilitates the Inactivation of the Kinase Akt by the Phosphatase PHLPP1”Po-Hsien Huang, Hsiao-Ching Chung, Chih-Chien Chou, Huiling Wang, Su-Lin Lee, Hsiao-Ching Yang, Hao-Chieh Chiu, Naval Kapuriya,Dasheng Wang, Samuel K. Kulp, and Ching-Shih Chen,* Science Signaling (AAAS) 2013, 6 (267), ra19. [DOI: 10.1126/scisignal.2003816]

9.         “Probing Ligand Binding to Thromboxane Synthase” Wei-Chih Chao, Jyh-Feng Lu, Jinn-Shyan Wang,* Hsiao-Ching Yang, Tai-An Pan, Steven Chun-Wei Chou, Lee-Ho Wang, and Pi-Tai Chou Biochemistry 2013, 52, 1113.

10.     “Identification of Kazinol Q, a Natural Productfrom Formosan Plants, as an Inhibitor of DNAMethyltransferase” Jing-Ru Weng*, I-Lu Lai, Hsiao-Ching Yang, Chun-Nan Lin, and Li-Yuan Bai PHYTOTHERAPY RESEARCH Phytother. Res. 2013, DOI: 10.1002/ptr.4955.

11.     “Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator” Kuen-Haur Lee, En-Chi Hsu, Jih-Hwa Guh, Hsiao-Ching Yang, Dasheng Wang, Samuel K. Kulp, Charles L. Shapiro and Ching-Shih Chen,* Journal of Biological Chemistry 2011, 286 (45), 39247-39258.

12.     “Probing Interaction between Prostacyclin Synthase and Prostaglandin H2 Analogues or Inhibitors via Combination of Resonance Raman Spectroscopy and Molecular Dynamics Simulation Approaches” Wei-Chih Chao, Jyh-Feng Lu, Jinn-Shyan Wang, Hsiao-Ching Yang,* Hsiao-Hui Chen, Yi-Kang Lan, Ya-Chien Yu, Pi-Tai Chou*, and Lee-Ho Wang J. Am. Chem. Soc. 2011, 133 (46), 18870–18879.

13.      “Carbene Rotamer Switching Explains the Reverse Trans Effect in Forming the Grubbs Second-Generation Olefin Metathesis Catalyst” Hsiao-Ching Yang,* Yen-Chin Huang, Yikang Lan, Tien-Yau Luh, Yan Zhao and Donald G. Truhlar* Organometallics 2011, 30 (15), 4196–4200.

14.     “Chiral Amplification in One-Dimensional Helical Nanostructures Self-Organized From Phenylethynyl Thiophene With Elaborated Long-Chain Dicarboxamides” Chun-Hsian Li, Kai-Chi Chang, Chia-Chen Tsou, Yikang Lan, Hsiao-Ching Yang,* and Shih-Sheng Sun* Journal of Organic Chemistry 2011, 76 (14), 5524–5530.

15.     “Enforced liquid crystalline properties of dibenzo[a,c]phenazine dimer and self assembly” Mei-Chun Tzeng, Su-Chih Liao, Tsu-Hsin Chang, Shih-Chi Yang, Min-Wei Weng, Hsiao-Ching Yang, Michael Y. Chiang, Zhang Kai, Jishan Wu and Chi Wi Ong* J. Mater. Chem. 2011, 21, 1704.